Computed tomography scan radiation and brain cancer incidence

NR Smoll; Z Brady; KJ Scurrah; C Lee; AB De González; JD Mathews

Journal article

Computed tomography scan radiation and brain cancer incidence

NR Smoll, Z Brady, KJ Scurrah, C Lee, AB De González, JD Mathews

Neuro Oncology | OXFORD UNIV PRESS INC | Published : 2023

DOI: 10.1093/neuonc/noad012

Abstract

Background: Computed tomography (CT) scans make substantial contributions to low-dose ionizing radiation exposures, raising concerns about excess cancers caused by diagnostic radiation. Methods: Deidentified medicare records for all Australians aged 0-19 years between 1985-2005 were linked to national death and cancer registrations to 2012. The National Cancer Institute CT program was used to estimate radiation doses to the brain from CT exposures in 1985-2005, Poisson regression was used to model the dependence of brain cancer incidence on brain radiation dose, which lagged by 2 years to minimize reverse causation bias. Results: Of 10 524 842 young Australians, 611 544 were CT-exposed befor..

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University of Melbourne Researchers

Zoe Brady Author

Katrina Scurrah Author

John Mathews Author

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Grants

Awarded by Australian Government

Funding Acknowledgements

This work was supported by the Australian Government through the National Health & Medical Research Council (NHMRC; grant numbers: 509190, 1027368, and 1084197). Role of the funder: The funding agency (NHMRC) had no role in the conduct of this research, nor in the manuscript preparation or decision to publish